KMID : 1004820130140010008
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Journal of Biomedical Research 2013 Volume.14 No. 1 p.8 ~ p.12
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Comparison of blood concentration for oral administration of micronized and non-micronized amoxicillin in Sprague-Dawley rats
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Ryu Yong-Jae
Cha Chun-Nam Yu Eun-Ah Park Eun-Kee Lee Beom-Jun Kim Suk Lee Hu-Jang
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Abstract
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Amoxicillin, a well-known antibiotic, has a broad spectrum against gram-negative and gram-positive bacteria. This experiment was conducted in order to investigate the effect of micronized and non-micronized amoxicillin prepared using different comminution techniques on change in blood concentration of rats. Forty adult male Sprague Dawley rats (6~7 weeks of age, body weight 128.3 ¡¾ 10.7 g) were randomly allocated to two treatment groups: micronized amoxicillin (MA) group treated with micronized amoxicillin trihydrate powder (particle size, over 90% of 10 ¥ìm), non-micronized amoxicillin (NMA) group treated with non-micronized amoxicillin trihydrate powder (particle size, over 70% of 100 ¥ìm), given 480 mg/kg body weight once daily for four days. The results showed a significant increase in serum concentration in the MA group on days 3 and 4, compared to the NMA group (P<0.05). In particular, serum concentration of the MA group on day 4 was increased almost two times that of the NMA group. The results indicate that due to the increase of the drug¡¯s oral bioavailability, higher serum concentration would be achieved with the micronized amoxicillin trihydrate than with the non-micronized drug.
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KEYWORD
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micronization, amoxicillin trihydrate, serum concentration, bioavailability, rats
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